Vector-Based Pathogenicity: A Novel Mathematical Metric for Transmembrane Mutations

This research seeks to establish a new mathematical framework—the "Directional Variant Metric"—specifically tailored for analyzing mutations within the complex geometry of transmembrane proteins. Unlike standard metrics, this approach accounts for the directional impact of amino acid substitutions relative to the lipid bilayer and membrane pore axis, offering a higher-resolution prediction model for channelopathies and transporter defects.